Co-dependency for MET and FGFR1 in basal triple-negative breast cancers
نویسندگان
چکیده
منابع مشابه
Correction: triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival
Correction After the publication of this work [1], we found that there were some mistakes in calculating the percentage of composition in Table 1 (1). Clinicopathologic characteristics of breast cancer subtypes. We are therefore providing the revised Table 1, with the updated data for rows ‘Mucinous carcinoma’, ‘Metaplastic carcinoma’ and ‘Others’. In the sub-content of Table 1, ‘Histological t...
متن کاملTreatment Options for Triple-negative Breast Cancers
grade (severity). Identification of molecular markers such as expression of the estrogen (er) and progesterone receptors (pgr) and the human epidermal growth factor receptor 2 (her2) has offered additional predictive value for the therapeutic assessment of women diagnosed with breast cancer 1–4. More recently, gene expression analysis using dna microarray technology has identified additional br...
متن کاملTargeting MET and EGFR crosstalk signaling in triple-negative breast cancers
There is a vital need for improved therapeutic strategies that are effective in both primary and metastatic triple-negative breast cancer (TNBC). Current treatment options for TNBC patients are restricted to chemotherapy; however tyrosine kinases are promising druggable targets due to their high expression in multiple TNBC subtypes. Since coexpression of receptor tyrosine kinases (RTKs) can pro...
متن کاملThe Relationship Between Fibroblastic Growth Factor Receptor-1 (FGFR1) Gene Amplification in Triple Negative Breast Carcinomas and Clinicopathological Prognostic Factors
Background & Objective: In Triple-Negative Breast Cancers (TNBCs), estrogen receptor (ER), progesterone receptor (PR) and HER2/neu genes are not expressed. Fibroblastic Growth Factor Receptor-1 (FGFR1) gene product is a protein that acts as a receptor of thyrosin kinase. It plays a role in the proliferation, differentiation, and migration of malignant cells. The objective was t...
متن کاملThe omics of triple-negative breast cancers.
BACKGROUND Triple-negative breast cancers (TNBC) do not represent a single disease subgroup and are often aggressive breast cancers with poor prognoses. Unlike estrogen/progesterone receptor and HER2 (human epidermal growth factor receptor 2) breast cancers, which are responsive to targeted treatments, there is no effective targeted therapy for TNBC, although approximately 50% of patients respo...
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ژورنال
عنوان ژورنال: npj Breast Cancer
سال: 2021
ISSN: 2374-4677
DOI: 10.1038/s41523-021-00238-4